Lecture 8

Question 1

For a backcross design in non-inbred parental lines, how do you have to treat the families?

Answer 1

There is a need for treating the families separately. Marker variances can be pooled across families but not the marker effects.

Question 2

What is the big problem with F2 design in non-inbred parental lines?

Answer 2

Heterozygous progeny for the marker are not informative, unless we have other liked markers, more extensive pedigree information, and proper methods.

Question 3

How does an F2 design with non-inbred parental lines work for Mm progeny?

Answer 3

we cannot tell if M came from the sire or the dam

Question 4

How does an F2 design with non-inbred parental lines work for MM progeny?

Answer 4

We can tell that the allele M was inherited from each parent (and similarly mm) if the parents are heterozygous, this is useful information, we are then left to contrast MM and mm progeny.

Question 5

In an F2 design with non-inbred parental lines, what does the distribution of progeny depend on?

Answer 5

the distribution of progeny depends on the frequencies and phases of QTL and marker alleles in the population of dams.