lecture 7- T cell differentiation and effector function

Question 1

How does a cell differentiate into TH1?

Answer 1

PAMPs from intracellular bacteria and viruses, cause
dendritic cells and macrophages to make IL12
and nk cells to make IFN-y

Question 2

How does a cell differentiate into TH2?

Answer 2

caused by IL4

Question 3

How does a cell differentiate into TH17?

Answer 3

PAMPs from extracellular bacteria and fungi cause

dendritic cells to make IL1, IL6, and IL23 (TGFb is also impt)

Question 4

What is the effect of Th1

Answer 4

To activate macrophages by classical pathway. increase Ros/NO, increase IL12 (more Th1), increase MHC, increase TNF (recruit lymphocytes)

Question 5

What do CD8+ Tcells do (aka CTLs) ?

Answer 5

they use perforin (to make a pore in the cell) and then inject granzymes (to induce cell to undergo apoptosis)

Question 6

What is the effect of Th2?

Answer 6

they mainly fight helminthes? promote eosinophil recruitment (IL-5)
IgE production (IL-4) 
alternative pathway of macrophage activation (IL-4 and IL-13)

Question 7

what is the effect of Th17?

Answer 7

IL17 and IL22 recruit neutrophils and defensins(epitherlial tissue). They mainly deal with extracellular pathogens

Question 8

The role of each Th1,2,17 in disease is?

Answer 8

Th1= autoimmune, chronic inflammation 
Th2= allergies 
Th17= autoimmunity