Lecture 7: SPECT - Brain and Bone

Question 1

Briefly describe a HMPAO scan protocol? (6 marks)

Answer 1

• SPECT scan used to differentiate between different types of dementia
• 500 MBq of Tc-99m used
• ED of 5 mSv
• Assesses diffusion across blood-brain barrier
• High res collimator used as localisation is key
• use FBP to obtain the images

Question 2

Briefly describe a DATSCAN scan protocol? (6 marks)

Answer 2

• SPECT scan to assist with Parkinsons or DLB diagnosis
• Uses 185 MBq of I-123 Iofluplane
• ED of 4 mSv
• Binds to dopamine transporters
• LEHR collimator used
• FBP used

Question 3

Briefly describe a bone scan protocol? (4 marks)

Answer 3

• Used to show blood flow and bone crystallisation
• 600 MBq of Tc-99m MDP
• LEHR as localisation is key
• Use geometric mean of results as less prone to variability with distance