Lecture 7 Skin and Systemic Disease

Question 1

Name skin conditions related to GI genetic diseases

Answer 1

 Hereditary haemorrhagic telangiectasia

 Blue rubber bleb naevus- develop anaemia from chronic GI bleeding

Question 2

Name skin conditions related to GI inflammatory/autoimmune diseases

Answer 2

• Erythema nodosum

* Pyoderma gangrenosum

Question 3

Vitamin deficiency can lead to__

Answer 3

Scurvy/Beriberi

Question 4

Name skin conditions related to diabetes

Answer 4

Acanthosis Nigricans
Diabetic bullae
Diabetic dermopathy
Eruptive xanthomas
Necrobiosis lipodica

Question 5

Name skin conditions related to hyperthyroidism

Answer 5

• Thyroid acropachy- thickening of the extremities and it is manifested by a triad of signs: digital clubbing, soft tissue swelling of the hands and feet, and periosteal new bone formation

Question 6

Name conditions associated with hypothyroidism

Answer 6

• Pre-tibial Myxoedema

Question 7

Name autoimmune skin conditions

Answer 7

Cutaneous lupus
Cutaneous vasculitis
Alopecia
Vitiligo

Question 8

Name skin conditions that would suggest an underlying malignancy

Answer 8

Carcinoid syndrome
Ectopic ACTH syndrome
Paget's
Extra-mammary Paget's
Paraneoplastic Pemphigus
Acquired Hypertrichosis Lanuginosa
Bazex Syndrome
Leser-Trelat

Question 9

Conditions associated with cancer

Answer 9

Acanthosis Nigricans

Dematomyositis

Question 10

Name conditions that may be associated with malignancy

Answer 10

• Bullous pemphgoid
• Sweets Syndrome- very rare inflammatory skin condition characterized by a sudden onset of fever and painful rash on the arms, legs, trunk, face, or neck
• Pyoderma gangrenosum
• Acquired ichthyosis
• Cryoglobulinaemia

Question 11

Name genetic tumour syndromes

Answer 11

• Peutz-Jeghers (d/d- HHT): melanosis, colon hamartomas, colon ca
• Muir-Torre: sebaceous tumours, keratoacanthomas, GI, breast, GU
• Neurofibromatosis: Café au lait, Ax freckles, Neurofibromas, nerve sheath, phaeoCCyT, carcinoid
• MEN syndromes: angiofibromas, neuromas, lichen or macular amyloid (MEN2), endocrine, P’s
• Howel-Evans: palmoplantar keratoderma, oesophageal