Lecture 7: Intro to DM Flashcards
What tests are used to test for DM?
HbA1c > 6.5%
Fasting BG > 126
2-hour Oral glucose tolerance test (OGTT) > 200
Random plasma glucose > 200 (if htn crisis)
How common is T1DM?
10% of all US adults.
What is the pathophysiology of T1DM?
Destruction of beta cells = no insulin production.
Often caused by autoimmune disease.
What is the pathophysiology of T2DM?
Insulin resistance.
Multifactorial, more dependent on diet and lifestyle.
What is the treatment of T1DM and T2DM?
T1DM must get insulin.
T2DM may get insulin.
How common is T2DM?
90% of adult DM Dx.
What is T3DM?
Alzheimer’s
Not actually diabetes
Why is Alzheimer’s related to DM?
Chronic insulin resistance and insulin insufficiency may play a role.
What counts as prediabetes?
Impaired fasting BG of 100-125
Impaired glucose tolerance of 140-199
Elevated HbA1c 5.7-6.4%
What is gestational DM?
DM that occurs during pregnancy that resolves after birth.
What are the general goals of DM and pre-DM management?
Maintain a normal or near-normal serum glucose level.
Prevent or reverse LIPID abnormalities
Prevent or delay complications.
What is glycemic control?
Controlling BG regardless of DM type.
T1 still need insulin, but can benefit from lifestyle modifications.
T2 can potentially be treated from just lifestyle modifications.
What are some general interventions one can make for DM management?
Healthy eating pattern, focusing on high fiber, medi style, low carbs, more plant-based.
Weight loss (Esp truncoabdominal fat loss)
Bariatric surgery (can boost glycemic control)
Avoid tobacco (worsens insulin resistance)
How little weight loss can start having benefits for DM?
5-10%
What is the macro distribution for DM?
No actual set.
Recommended:
Carbs/high fiber: 30g/day
Fats: focused on MUFA and PUFA
Protein: 0.8g/kg/day
What fats are associated with worse DM outcomes?
Saturated and trans fats
In what kind of patient is excess protein dangerous?
CKD (stages 3-4)
What protein type is recommended for DM pts?
Plant based
What is the general consensus about macros?
Excess carbs = obesity.
No RCTs have supported that statement. Carbs are not less healthy than fats/proteins.
Is a Keto diet good for DM? What are the pros and cons?
Pros:
Fast initial weight loss
Early improvements in BG
Cons:
Keto flu
Long-term compliance
Overall: no major differences in glycemic control after 1 year.
What is the best diet for a DM pt?
The one they are compliant with and adhere to.
What is more important between eating healthy foods and eating macros?
Eating healthy foods is best since it sustains better gut flora and is more sustainable.
What resources are available for DM pts to make diets?
Plate methods
Diabetic recipes
Diet exchange lists
When are diet exchange lists especially useful?
Pts counting carbs/reliant on insulin.
1 unit of rapid-acting insulin = 12-15g of carbs.