Lecture 6 - Sulfonamides, Quinolones, Metronidazole

Question 1

Sulfonamides MOA

Answer 1

Inhibit bacterial growth by interferon with microbial folic acid synthesis - PABA

Bacteriostatic

Question 2

Sulfasalazine

Answer 2

Absorbed in upper GI tract, returned to colon in bile

used for IBD, Ulcerative colitis, Crohn’s disease

Gets converted in colon to sulfapyridine + 5 aminosalicyclic acid (active form)