Lecture 6 Flashcards
What do the mechanical effects on the PDL cells cause the release of?
- Cytokines
- Prostaglandins
- Chemical messengers
What happens to blood flow on the compressed PDL area?
-It decreases
What happens to blood flow on the PDL under tension?
-It increases
What does the alterations in blood flow create?
-Changes in oxygen/carbon dioxide levels
When a force is applied to a tooth the fluids are expressed out of what area?
The PDL space
When the blood flow through the partially compressed PDL decreases the chemical environment produces what?
- Increases in Prostaglandin E,
- Increase in IL-1 Beta
- Increase in cAMP
Is a prostaglandin release a primary or secondary response to pressure?
-Primary
T/F Prostaglandins stimulate both osteoclastic and osteoblastic activity
True
cAMP levels typically increase after how many hours of sustained pressure?
-4-6 hrs
If a removable appliance is worn less that how many hows per day it will not have any orthodontic effects?
Less than 6 hrs
What are the two thresholds for tooth movement?
- 5-10 grams/square cm of force
- 4-6 hrs of sustained pressure
If you have to much force and continuous pressure what happens to the blood vessels at the PDL?
-The blood vessels are totally occluded and a sterile necrosis of PDL tissue ensues
T/F When the PDL is compressed to the point that blood flow is totally cut off, differentiation of osteoclasts within the PDL space is no longer possible
True
After a delay of several days, osteoclasts within the adjacent marrow spaces attack the underside of the lamina dura in a process called what?
-Undermining resorption
During undermining resorption what causes tooth movement to be delayed?
- Delay in the stimulation of differentiation of the cells
- Delayed due to the thickness of bone that must be removed from the underside