Lecture 5 - Reproductive Toxicology

Question 1

What dose of Xray is teratogenic?

Answer 1

dose (Rad)

5000 - abortion
50 - microcephaly, mental retardation
5 - counseling threshold

0. 5 no effect
1. 05 background

Question 2

Mutagenesis

Answer 2

changing the genetic code

Ames test -tests for possible mutagenesis by testing the drug with a mutated bacteria to determine if it back mutates to need an AA in the media to grow

Question 3

What is the risk of malformation (baby with birth defect) in the average woman?

Answer 3

3-4%

Question 4

Selective embryotoxicity

Answer 4

occurs at a level that is not toxic to the mother