Lecture 5: Cardiology Flashcards

1
Q

chest pain

A
  • frequent pediatric complaint
  • most pediatric chest pain is musculoskeletal in origin
  • older children are more likely to have psychogenic reasons
  • younger children are more likely to have a cause related to respiratory disease
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2
Q

chest pain etiologies

A
  • etiologies
    • musculoskeletal (>20% prevalence)
    • idiopathic (>20% prevalence)
    • psychogenic/psychiatric (<30% prevalence)
    • respiratory disorders (<10% prevalence)
    • gastrointestinal (<8% prevalence)
    • cardiac (<6% prevalence)
    • breast (<5% prevalence)
    • pulmonary vascular disorders
    • toxic exposure
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3
Q

approach to chest pain

A
  • distinguish acute vs. chronic
  • distinguish pleuritic from non-pleuritic
  • identify co-morbid risk factors
  • herald signs of serious causes (red flags)
    • chest pain with exertion
    • exertional syncope
    • acute pain that is acutely worsening
    • acute onset of fever with chest pain
    • findings on history or exam referable to cardiac or respiratory systems
  • rule out severe distress
  • chest tenderness is very reassuring against a cardiac source
  • initial workup typically starts with EKG and chest plain film
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4
Q

musculoskeletal source of chest pain

A
  • chest tenderness with or without movement
  • overuse injury or strain of chest wall muscle
  • direct trauma
    • rib fracture
    • contusion of chest wall
  • precordial catch (Texidor’s twinge)
    • sharp pain at the left sternal border, lasts less than 3 minutes, associated bubble or popping sensation
  • costochondritis
    • pain at sites of costal cartilage reproduced by eliciting tenderness over the costochondral junctions or with AP compression of the chest
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5
Q

respiratory source of chest pain

A
  • illnesses with persistent or forceful cough
  • pneumonia +/- pleural effusion
  • asthma +/- pneumomediastinum
  • spontaneous pneumothorax
    • asthma
    • cystic fibrosis
    • Marfan’s syndrome
  • pleurisy
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6
Q

pulmonary vascular disorder source of chest pain

A
  • pulmonary embolism
    • rare in children but can occur in those with risk factors
      • oral contraceptives
      • termination of pregnancy
      • trauma, particularly of lower extremities
    • classic presentation
      • acute onset of pleuritic chest pain, dyspnea, hypoxia
      • presentation is not always classic
  • pulmonary hypertension
    • pain typically related to underlying heart or lung disease
  • acute chest syndrome
    • chest source crisis in patients with sickle cell disease
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7
Q

psychogenic source of chest pain

A
  • anxiety disorder or conversion disorder
    • relative or friend with cardiac disease
    • family history of depression, somatization
    • triggered by stress
  • hyperventilation
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8
Q

GI source chest pain

A
  • reflux esophagitis
    • burning, substernal pain
      • worse with reclining or certain foods
    • may be associated with esophageal spasm (mimicks angina)
    • severe cases complicated by esophageal candidiasis
  • intrathoracic foreign body
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9
Q

mammary source chest pain

A
  • females
    • mastitis
    • pregnancy
    • fibrocystic disease
  • males
    • gynecomastia
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10
Q

cardiac source chest pain

A
  • Rare cause of chest pain in children
  • Co-morbid risk factors raise likelihood of cardiac-source chest pain
    • diabetes mellitus
    • Kawasaki’s disease
    • stimulant use
      • cocaine
      • amphetamines
  • cardiac ischemia
    • may result from
      • anomalous coronary arteries
      • left ventricular outflow tract obstruction (LVOTO)
      • cardiac infection - endocarditis
      • embolic phenomena
      • Vasculitis
      • pulmonary hypertension
      • valvular disease (congenital or acquired)
      • cardiomyopathy
      • subaortic stenosis
      • arrhythmia
  • myocardial infarction
    • rare in children
    • herald sign – pain with exertion
  • mitral valve prolapse
  • pericarditis and myocarditis may cause chest pain without ischemia
  • hypertrophic obstructive cardiomyopathy (HOCM)
    • autosomal dominant inheritance
    • systolic murmur worsening with change from lying to standing or with squat to standing or Valsalva
      • procedures that reduce blood return to ventricles (reduce preload).
    • pain with exertion
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11
Q

cardiac infections: pericarditis

A
  • inflammation of the pericardium
    • fever
    • respiratory distress
    • sharp, stabbing substernal chest pain
    • often unable to lie flat
    • pain improves with sitting up or leaning forward
    • friction rub, distant heart sounds
    • jugular venous distension
    • pulsus paradoxus
    • Abnormal EKG – Diffuse ST elevations
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12
Q

cardiac infections: myocarditis

A
  • inflammation of the heart muscle
    • pain develops over a few days
    • fever
    • systemic symptoms consistent with CHF
      • vomiting, lightheadedness, etc.
    • gallop rhythm (S3, S4 sounds)
    • Tachycardia, hepatomegaly
    • orthostatic hypotension
    • CXR - cardiomegaly
    • abnormal EKG, elevated CK and troponins
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13
Q

pediatric arrhythmias

A
  • sinus arrhythmia can be very pronounced in children
    • HR slows with expiration
  • most common pediatric dysrhythmia is supraventricular tachycardia
  • mechanisms include
    • intra-atrial reentry
    • AV nodal reentrant tachycardia
    • AV accessory conduction
      • Wolff-Parkinson-White syndrome
      • slurred upstroke of the QRS (delta wave) à
  • Babies normal heartrates when they’re born are 130-160, a 2-3yo is around 100 etc. so tachycardia for younger ones is different than tachy in an adult
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14
Q

approach to chest pain

A
  • distinguish acute vs. chronic
  • distinguish pleuritic from non-pleuritic
  • identify co-morbid risk factors
  • herald signs of serious causes (red flags)
    • chest pain with exertion
    • acute pain that is acutely worsening
    • acute onset of fever with chest pain
    • findings on history or exam referable to cardiac or respiratory systems
  • rule out severe distress
  • chest tenderness is very reassuring against a cardiac source
  • initial workup typically starts with EKG and chest plain film
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15
Q

describing a murmur

A
  • intensity (grade I-VI)
  • quality
  • timing
    • relationship to cardiac cycle
    • Duration
    • “shape”
  • location
  • variation with position
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16
Q

qualities of an innocent heart murmur

A
  • Early Systolic Ejection
  • Short Duration
  • Soft - Low intensity (Grade 1 or 2)
  • Vibrating or musical quality
17
Q

qualities of a pathologic murmur (one or more)

A
  • Pansystolic
  • Diastolic(except venous hum)
  • Long loud systolic murmurs
18
Q

innocent murmurs

A
  • roughly 80% of kids have a murmur at some time in their lives
    • “innocent” is synonymous with terms functional, benign, & flow
      • peripheral pulmonic stenosis
      • Still’s (vibratory) murmur
      • venous hum
      • carotid bruit
19
Q

innocent murmurs: peripheral pulmonic stenosis (PPS)

A
  • peripheral pulmonic stenosis (PPS)
    • caused by turbulence in the branches of the pulmonary artery in neonates
    • grade I-II
    • soft, short, high-pitched
    • loudest over LUSB
    • radiates to back & axillae
    • Resolves by 3 to 6 months
  • With a VSD, even the process of breast feeding is something that will make the baby SUPER tired
20
Q

innocent murmurs: still’s (vibratory) murmur

A
  • heard from age 2 and up
  • grade I-III
  • musical, vibratory, short
  • LLSB to apex
  • loudest when patient is in the supine position; diminishes when the patient sits or stands
21
Q

innocent murmurs: venous hum

A
  • heard after age 2
  • continuous musical hum
  • located at the upper right and left sternal borders
    • usually louder on the right
  • intensity changes with turning of the neck
  • Goes away when the patient lays down
22
Q

innocent murmurs: carotid bruit

A
  • any age
    • more common in the older child and adolescent
  • grade II-III
  • long, systolic ejection murmur
  • heard in right supraclavicular area
  • radiates to neck
23
Q

congenital heart disease

A
  • Shunts
    • systemic (left) and pulmonary (right) circuits generally operate in series
    • a shunt implies a connection that allows communication between the two systems
    • shunting proceeds down gradient in pressure
    • right-to-left shunts cause cyanosis
24
Q

acyanotic congenital heart disease

A
  • ASD, VSD, PDA
  • semilunar valvular defects
  • coarctation of the aorta
  • VSD accounts for about 25% of all CHD
  • ASD or PFO places patients at risk for systemic embolism
  • PDA covered in neonatal lecture
  • aortic stenosis and pulmonic stenosis are uncommon
    • AS 5% of all CHD, PS 10% of all CHD
    • both at risk for endocarditis
25
Q

ventricular septal defect

A
  • Small VSD
    • 80-85% of VSDs
    • asymptomatic
    • generally close on their own without surgery
  • Moderate VSD
    • serially monitored by cardiologists
  • Large VSD with normal pulmonary vascular resistance
  • left-to-right shunting as pulmonary vascular resistance naturally decreases (2-8 weeks of life)
  • infant develops congestive heart failure
    • failure to thrive
    • difficulty feeding
    • labored breathing/pulmonary edema
26
Q

Eisenmenger’s syndrome

A
  • an untreated large VSD will cause pulmonary overcirculation
  • overcirculation of pulmonary system causes pulmonary hypertension
  • normal left-to-right shunt reverses to right-to-left shunt as pulmonary system pressures surpass systemic pressures
  • prolonged cyanosis
    • causes organ and vascular damage
    • platelet dysfunction
    • treatable only with heart transplant
27
Q

coarctation of the aorta

A
  • main artery to body stenotic or interrupted
  • causes upper extremity hypertension and reduced flow to abdominal organs and lower extremities (SBP different by 20 should raise concern)
  • all newborns screened for femoral pulses and saturations
  • mild cases may have long-term growth problems,
    • often have aortic valve abnormalities audible on exam
    • may have chronic leg discomfort or lower extremity wasting
  • in severe cases with pre ductal coarctation the PDA needs to be kept open to ensure survival
    • if PDA closes, shock and acidosis ensue rapidly
28
Q

cyanotic CHD

A
  • five most common cyanotic CHD
    • truncus arteriosus
    • transposition of the great arteries
    • tricuspid atresia
    • tetralogy of Fallot
    • total anomalous pulmonary venous return
29
Q

tetralogy of fallot

A
  • ~10% of all congenital heart disease
  • four components to defect
    • ventricular septal defect
    • pulmonary stenosis
    • right ventricular hypertrophy
    • overriding aorta
  • The patient may be ‘pink’ (not cyanotic) if pulmonic stenosis mild and VSD shunts left to right
  • “Tet spells” where patient grows cyanotic, progressively worse with age
    • infants become agitated, tachypneic and have difficulty feeding
    • toddlers may squat to resolve Tet spell
  • long systolic ejection murmur (from PS)
  • classic CXR appearance - boot-shaped heart
  • surgically repaired in infancy
  • Tet spells are medical emergencies: SOB, cyanosis, loss of consciousness
    • Squatting helps to fix these
30
Q

rheumatic fever

A
  • follows a previous infection with Strep pyogenes (GAβHS) – rate in untreated is approx. 3%
  • typically between ages 5 and 15 years
  • mortality of 2-5%
  • pathophysiology
    • sensitization of B lymphocytes
    • formation of anti-streptococcal antibodies
    • formation of Immune complexes
    • myocardial & valvular inflammatory response
  • major criteria JONES criteria (mnemonic J<3NES) –
  • 2 major criteria make the diagnosis
    • joints – migratory polyarthritis
    • carditis
      • as myocarditis, pericarditis or valvular disease
    • nodules (subcutaneous)
      • extensor surfaces of extremities
    • erythema marginatum
      • pink-red macules grow, then coalesce into serpiginious long patches
    • Sydenham’s chorea – uncontrolled movements
      • with or without psychiatric disease
      • may define disease as a single criterion
  • 1 major + 2 minor can also signify disease
  • Minor criteria
    • polyarthralgia
    • fever
    • elevated ESR, CRP
    • prolonged PR interval
    • Previous rheumatic fever
  • Supportive serology of previous infection
    • anti-streptolysin O is the best test
    • anti-DNAse B & streptozyme also used
31
Q

rheumatic fever treatment

A
  • antibiotics
    • short-term to treat indolent infection
    • long-term to prevent recurrence
      • often every 3-4 weeks for life
  • aspirin for anti-inflammatory effects
    • sometimes requires corticosteroids
  • supportive
    • cardiac meds (digoxin, diuretics)
    • endocarditis prophylaxis for procedures
32
Q

infective endocarditis

A
  • greatest risk is to those with preexisting heart disease or cardiac foreign material
  • may be acute or subacute
  • viridans streptococci
  • S. aureus
  • less common
    • enterococci
    • HACEK organisms (fastidious Gram-negative rods)
  • fever
  • chest pain
  • symptoms of heart failure
    • fatigue, tachypnea, dyspnea on exertion
  • changing murmur
  • petechiae & embolic phenomena
  • splenomegaly +/- hepatomegaly
  • arthritis
  • weight loss (subacute or chronic illness)
  • Bacteremia with positive blood cultures
  • hematuria
  • markedly elevated inflammatory markers
33
Q

treatment of infective endocarditis

A
  • treatment
    • long-term antibiotics
      • directed therapy (based on cultures)
    • surgical excision or valve repair sometimes warranted
    • supportive care for sequelae
      • congestive heart failure
  • use transthoracic echos first and blood cultures, etc.
  • Has to be treated for a very long time
34
Q

endocarditis prevention

A
  • cardiac risk factors that are often indications for prophylaxis
    • prior history of infective endocarditis
    • any valvulopathy
    • prosthetic heart valves
    • unrepaired cyanotic CHD
    • repaired CHD with prosthetic material, device or venous pacer wires
  • risk of procedure also important to determine need
    • dental/oral or upper respiratory tract
      • amoxicillin
    • GU/GI procedures
      • amoxicillin for enterococcal coverage
      • aminoglycoside - for gram-negative coverage
    • procedures that involved infected tissues
      • clindamycin or vancomycin to cover MRSA
35
Q

chest pain history

A
  • Pain is in the center of the chest over the past 3 days.
  • No history of chest pain
  • Pain is worse with deep breathing
  • No fever
  • He has been coughing
  • No history of pain with activity, some increase in symptoms while active
  • No history of fainting
  • No family history of cardiac disease