Lecture: 5: Antibody Therapies Flashcards
1
Q
What are the differences between IgM, IgG, IgA, IgD, and IgE?
A
IgM is produced within the first 24 hours of infection, they are pentameric to make up for the fact that they have less binding affinity than IgG.
IgG is produced by primed B-cells and is more specific.
IgA is found mostly in mucous and secreted from B-cells in places such as MALT.
IgE is involved in allergic responses
2
Q
What are the three types of MAB? (origin)
A
Murine MAB
Chimeric MAB
Human MAB
3
Q
What is an Fc fusion protein?
How does it differ from MABs?
A
Fc fusion proteins are
4
Q
Why is Her2 implicated in cancer?
A
5
Q
How do Pertuzumab and Trastuzumab help in Her2-positive breast cancer?
A
6
Q
Why is Pertuzumab better at treating Her2-positive breast cancer?
A
