Lecture 5 Flashcards
Microtubules consist of tubulin which is comprised of heterodimeric globular subunits formed from ____ and ____ monomers.
ALPHA and BETA monomers.
Beta subunit hydrolyzes _____ once the heterodimer is incorpoated into the filament.
GTP
The wall of MTs consists of 13 _____.
PROTOFILAMENTS
MT assembly occurs at organizing centers such as Centrosomes with 2 ____ and ____ basal bodies.
Centrosomes with 2 CENTRIOLES and FLAGELLAR basal bodies.
MAP 1 is distinct from MAP 2 and Tau in that it is not associated with ____ cells.
NEURONAL
MAPs (microtubule associate proteins) help not only to stabilize MTs, but also to ____-____ them.
CROSS-LINK them
____ is an antimitotic drug from the bark of ____ trees. It is anit-leukemic and tumor inhibiting. It inhibits cell division via stimulation _____ polymerization, binding and stabilizing MTs, and enhancing ____ associations between MTs. This creates compact MT _____, which inhibits their function and, thus, _____ division.
TAXOL is antimitotic drug from the bark of YEW trees. Anti leukemic and tumor inhibiting. Inhibits cell division via stimulation of TUBULIN polymerization, binding and stabilizing MTs, and enhancing LATERAL associations between MTs. This creates compact MT BUNDLES, which inhibits their function and, thus, CELL division.
_____ is a drug that promotes MT disassembly via binding to a heterodimeric subunit and preventing it from being added to the _____ end of the MT.
COLCHACINE is a drug that promotes MT disassembly via binding to a heterodimeric subunit and preventing it from being added to the PLUS end of the MT.
MTs are found in cilia, Flagella, basal bodies, centrioles, and mitotic _____.
SPINDLES
Elongated cells, such as erythrocytes, lens epithelial cells, or nerve ganglion cells, that are treated with Colchacine will become _____ in shape.
SPHERICAL
