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BIEN 138: Wound Repair > Lecture 5-6 Notes > Flashcards

Lecture 5-6 Notes Flashcards

1
Q

What are the cell integrin receptors for Collagen IV?

A

a2B1

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2
Q

What are the cell integrin receptors for Laminin?

A

a6B4, a3B1

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3
Q

What are the cell integrin receptors for Fibronectin?

A

a5B1, avB3, a4B1, a3B1

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4
Q

What are the cell integrin receptors for Fibrin?

A

avB3

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5
Q

Integrins act as “molecular boots”. What does this mean?

A

?

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6
Q

What are some leukocyte integrins?

A

aL, aM, aX, and aD

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7
Q

What are filopodia?

A

Spike-like actin that is arranged in long bundles.

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8
Q

What are lamellipodia?

A

Flat and fan like actin that is branched.

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9
Q

Of the following steps of cell migration on ECM, which are dependent on integrin?

(i) Sensing
(ii) Extension
(iii) Attachment
(iv) Contraction
(v) Rear release
(vi) Recycline

A

iii, iv, and v
Attachment, contraction and rear release
These steps are most associated with the actual movement process.

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10
Q

Are the lamellipodia or filopodia active during the sensing step of cell migration?

A

Filopodia

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11
Q

Are the lamellipodia or filopodia active during the extension step of cell migration?

A

Lamellipodia

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12
Q

What are four ways or functions that polarity complexes take roles in?

A

Epithelial polarity, asymmetric division, cell migration, immunological synapse

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13
Q

State 5 features of epithelial cells.

A
  1. They have cell polarity
  2. Cell adhesion is in place between cells and between cells and the ECM
  3. They are stationary
  4. They have a high level of E-cadherin
  5. They have a low level of N-cadherin
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14
Q

State 5 features of mesenchymal cells.

A
  1. They have no cell polarity
  2. They have no cell adhesion
  3. They have the ability to migrate and invade
  4. They have a low level of E-cadherin
  5. They have a high level of N-cadherin
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15
Q

What is N-cadherin?

A

A protein that mediates cell-cell adhesion for cell migration

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16
Q

What is E-cadherin?

A

A protein that mediate cell-cell adhesion for binding cells to one another

BIEN 138: Wound Repair (2 decks)

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