Lecture 5 Flashcards
Autonomic nervous system is responsible for ensuring _____
Homeostasis
Homeostasis
Response to internal and external stimuli to ensure a stable environment
Two neuron chain (2 types)
Presynaptic and postsynaptic
Autonomic nervous system controls everything except
Skeletal muscle
Two divisions of autonomic nervous system
Sympathetic and parasympathetic
Thoracolumbar division of sympathetic
Pre-synaptic fibers leave spine at the level of the thoracic vertebra and upper lumbar
Sympathetic synapse where
Paravertebral (sympathetic) chain
Sympathetic presynaptic are
Short
Sympathetic innervates
walls of organs, glands, and smooth muscle
Sympathetic post synaptic are
Long, lots of branching, diffuse effects
Which is the fight or flight division?
Sympathetic
Fight or flight is mediated through
Mostly epinephrine and norepinephrine release on target organs
Craniosacral division of parasympathetic
Pre-synaptic fibers leave spine at the level of Cn 3,7,9,10 and the sacrum
Parasympathetic synapse where
In or near target organ
Parasympathetic nervous system innervates
Walls of organs, glands, and smooth muscle
Parasympathetic presynaptic are
long???
Parasympathetic postsynaptic are
Short, less branching, discrete effects
Which is the rest and digest division?
Parasympathetic
Parasympathetic is mediated through
Acetylcholine release on target organs
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PNS neurotransmitters
ACH pre and post synoptically
PNS postsynaptic receptor
Nicotinic
PNS target receptor
Muscarinic
SNS neurotransmitters
Ach in pre, varied in post
Usually norepinephrine
SNS - eccrine sweat glands NT
Ach
SNS - kidney NT
Dopamine
SNS - adrenal medulla functions as
post-synaptic neuron
Varicosites
ANS ganglia form varicosities where NTs are stored
NTs are stored where?
In large vesicles with other neurotransmitters (ATP, VIP, etc.)
Neurotransmitters released onto _____ and multiple places
smooth muscle
CASE QUESTION (13)
CASE QUESTION (13)
Both divisions of the ANS have _____ receptors on their post-synaptic nerves
Nicotinic
Pre-synaptic neuron releases _____ on post-synaptic nerve
Ach
PNS - muscarininc receptors on target organs
M2, M3
M2
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M3
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You can live without _____, but not without _____
Sympathetic
Parasympathetic
SNS - adrenergic receptors on target organs (mostly)
a1, a2, B1, B2
a1
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a2
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Usually regulate release of epic and norepi
Modulate sympathetic response via negative feedback
Mechanism?
B1
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B2
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Most organs are _____ innervated by the ANS
Dually
Two divisions work together to maintain _____ or get desired effect
Homeostasis
Usually have opposite effects
Maximal dual innervation effect
Requires full stimulation by one and a full stop of stimulation by the other
In most organs resting tone from _____ predominates
PNS
