Lecture 5

Question 1

What is order of bond weakness

Answer 1

Most weak = pi bond
Middle = L-C
Strongest = C=C

Question 2

Acid anhydride

Answer 2

Question 3

Consequence of L group

Answer 3

C=O group can be further polarised
- more electron withdrawing —> more reactive - attractive to Nu:-

Question 4

Reactivity of L groups

Answer 4

Question 5

AMIDE less reactiv e because

Answer 5

Question 6

Preparation of reactive carboxyllic acid derivatives - ANHYDRIDES

Answer 6

Question 7

Preparation of reactive carboxylic acid derivatives - ACID CHLORIDES

Answer 7

Question 8

When a weak nucleophille (in nucleophillic acyl substitution with anhydrides) what happens

Answer 8

Deprotonation step after attack

Question 9

Nucleophillic Acyl substitiurtion with reactive Acod derivatives - ANHYDRIDES

Answer 9

Question 10

Nucleophillic acyl substitution won’t reactive acid derivatives - ACID CHLORIDE

Answer 10

Question 11

unreatvice acid derivatives

Answer 11

• amides
• carboxyllic acids
• esters

WITH NEUTRAL NEUCLEOPJHILSS

Question 12

Carboxylic acid reaction

Answer 12

Question 13

Amide hydrolysis

Answer 13

Question 14

Fats, oils, waxes and lipids

Answer 14

• naturally occurring substances that can be extracted from cells by non-polar solvents

Question 15

Hydrolysis of fats

Answer 15

Question 16

How does soap work

Answer 16

• forms a cloudy solution of spherical micelles
• the hydrophobic hysrecarbon chains cluster together in the middle of the Michele
• the polar (hydrophilic) carboxylate groups are often on the surface
• oil and dirt dissolve in the non polar part of the Michelle