lecture 5 Flashcards

1
Q

Alpha-BSM applications?

A

Dental Applications & Orthopedic

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2
Q

controls drug release in ocusert?

A

EVA: Ethylene-vinyl acetate

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3
Q

drugs used in the gastro-retentive system?

A
  • Drugs with limited acid solubility: Phenytoin
  • Drugs that suffer instability in gastric environment erythromycin
  • Drugs intended for selective release in colon: 5-Amino-Salycilic Acid
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4
Q

factors that affect gastric retention?

A
  • density of dosage form
  • shape & size of dosage form
  • food intake & its nature
  • Gender & Age
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5
Q

Mechanism of MucoAdhesion?

A
  • Wetting theory
  • Diffusion theory
  • Chemical Bond formation: Primary (Covalent)& Secondary (Van der waals & hydrogen bond)
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6
Q

Mucoadhesion characteristics?

A
  • flexibility
  • hydrophilicity
  • hydrogen bonding
  • high mwt
  • low surface tension
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