Lecture 4 - STDs

Question 1

chlamydia:

serovars ____ cause urethritis/PID, noenatal _____ and neonatal _____

Answer 1

D-K;
pneumonia, conjunctivitis

14 day inxcubation

Question 2

chlamydia:
Types L1-L3 cause _____, which are small painless ulcers on genitals that progress to swollen (painful or painless) _____ lymph nodes that ulcerate. treat with _____

Answer 2

lymphogranuloma venereum;
painful, inguinal;
doxycycline

Question 3

chlamydia:
cytoplasmic inclusions (\_\_\_\_ bodies) are seen on \_\_\_\_\_ stained smear. can also do PCR, \_\_\_\_\_ \_\_\_\_\_ amplification

Answer 3

reticulate;
giemsa;
nucleic acid

Question 4

what do you use to treat chlamydia?

which only requires one time treatment?

Answer 4

doxy or azithromycin;

azithromycin = 1 time

Question 5

gonorrhea: causes a ____ discharge;

chlamydia causes a ____ discharge

Answer 5

purulent/creamy;

watery

Question 6

Neisseria gonorrheae:
encapsulated?
why can’t we have a vaccine for it?

Answer 6

no;

antigenic variation of pilus

Question 7

gonorrhea:

can cause fitz-hugh-curtis syndrome, which is infection of the ___ ___ and violin string adhesions of ____ to _____

Answer 7

liver capsule;

liver, peritoneum

Question 8

what kind of arthritis does gonorrhea cause:
symmetric or assymetric?
mono or polyarthralgia?

Answer 8

assymetric polyarthralgia

Question 9

treatment of gonorrhea:

Answer 9

ceftriaxone + azithromycin

along with partners

Question 10

3 most common causes of genital ulcers?

Answer 10

HSV, syphilis, chancroid

Question 11

genital ulcers--painful or painless?
HSV = 
syphilis = 
chancroid = 
granuloma inguinale =

Answer 11

painful, painless, painful, painless

Question 12

chancroid:
caused by _____
painful genital ulcer with _____; _____ adenopathy

Answer 12

hemophilus ducreyi;

exudate, inguinal

Question 13

granuloma inguinale:
caused by _____;
causes painless beefy red ulcer that ______;
no ______

Answer 13

klebsiella;
bleeds on contact;
lymphadenopathy

Question 14

genital herps:
progression of lesions = ____ –> ____ –> ____;
systemic symptoms or no?
lymphadenopathy or no?

Answer 14

vesicles –> ulcers –> crusts;
systemic symptoms )ie fever, etc)
lymphadenopathy

Question 15

secondary syphillis:
\_\_\_\_ rash (does it include palms and soles?), \_\_\_\_ \_\_\_\_ (smooth, moist painless wart like lesions), lymphadenopathy

Answer 15

maculopapular rash, including palms and soles;

condyloma lata;

Question 16

tertiary syphillis:
gummas, which are chronic _____;
____ due to destruction of vasa vasorum, neurosyphillis which includes ____ and general ____

Answer 16

granulomas;
aortitis;
tabes dorsalis, general paresis

Question 17

syphillis:
non-treponemal tests include ____ and ____;
treonemal tests include _____ and ____

Answer 17

VDRL, RPR (lot of false positives, non specific)
FTA-Abs, ELISA

current algorithms start with FTA-Abs

Question 18

jarisch-herxheimer syndrome:

_____ syndrome after antibiotics are started due to ____ releasing ____-

Answer 18

flu-like;

killed bacteria; toxins (ie LPS)

Question 19

granuloma inguinale:

microscopy shows _____ bodies, which are ____ staining. are they nuclear or cytoplasmic?

Answer 19

donovan, bipolar;

cytoplasmic

Question 20

treat granuloma inguinale with _____ or ____

Answer 20

azithromycin, doxy