Lecture 4 Particle RT & Cyberknife

Question 1

What is direct effect and indirect effect?

Answer 1

Direct effect: radiation damage caused by radiation particles directly interact with DNA

Indirect effect: radiation produce secondary particles after interaction with atoms, then these particles interact with DNA and cause damage

Question 2

Name 2 types of DNA damage.

Answer 2

Single strand break (SSB)
Double strand break (DSB)

Question 3

The ratio of radiation damage to cancer cells VS normal cells is called the ___________.

Answer 3

Therapeutic ratio

Question 4

What do the proton therapy system consist of?

Answer 4

• accelerators (cyclotron or synchrotron)
• energy selection and beam transport system
• beam delivery (fixed beam)
• beam delivery (gantry)

Question 5

Cyclotron or synchrotron accelerates proton to ___________ energy.

Answer 5

230MeV