Lecture 4-MS/MG Flashcards
a slowly progressive demyelinating disorder og the CNS
MS
patho of MS
- attack of myelin sheath
- CNS WHITE MATTER LESIONS SEPARATED BY TIME AND SPACE
area primarily affected in MS
white matter of cervical and dorsal region of lateral and posterior columns
-also optic nerves and periventricular areas
characteristics of MS
visual changes
- dizziness
- numbness
- incoordination
- dysdiadochokinesia (difficulty with RAMs)
avg age of onset of MS
30
most common neurologic disability beginning in early to middle adulthood
MS
most frequent presentations of MS
- fatigue
- paresthesias of extrem.
- clumsiness or weakness
- visual disturbances
signs of MS
internuclear ophthalmoplegia, lhermitte’s sx, optic neuritis, pyramidal tract involvement results (hyperreflexia, clonus), cerebellar involvement, posterior column involvement (reduced vibration and proprioception)
what is internuclear ophthalmoplegia
lesion in mlf
-paresis of medial rectus muscle on lateral conjugate gaze, but not on convergence
what is lhermitte’s sx
neck flexion sends sensation of elevtrical shock down back to legs
what is optic neuritis
decreased visual acuity, defective pupillary reaction to light
what is marcus gunn pupil
afferent pupillary defect
relapsing-remitting MS
- most common
- attacks of sxs that come on over 1-2 weeks and resolve in 4-8 weeks
secondary progressive MS
relapsing-remitting at first, then evolves to relapsing progressive
primary progressive MS
gradual preogression
