Lecture 4: Medical Cannabis

Question 1

2 types of endocannabinoids

Answer 1

Anandamide and 2AG
regulates: appetite, pain, stress and anxiety, learning and memory

Question 2

2 types of phytocannabinoids

Answer 2

THC and Cannabidiol (CBD)

Question 3

THC

Answer 3

CB1 and CB2 agonist
disrupts normal endocannabinoids signalling from dopaminergic neurons

CB1 and CB2 receptor inhibit dopamine release
long term activation lead to desensitization of CB1 and CB2 receptor cause the loss of inhibition
lead to more release of dopamine

Question 4

Cannabis use disorder

Answer 4

dependence, feel withdrawal symptoms when not taking the drug
become addition when the person cannot stop using the drug when it interferes many aspect of life

Question 5

Cannabis use in humans is associated with?

Answer 5

Reduced dopamine in striatum
reduced dopamine synthesis and release
correlated to negative emotions and addiction severity

Question 6

CB receptors and pain

Answer 6

endocannabinoids levels are increased during pain
activation of CB receptors reduce pain

Question 7

Cannabis and cannabinoids have clinical evidence in the treatment for?

Answer 7

pain and multiple sclerosis
nausea and vomiting
potential epilepsy treatment due to inhibition of liver metabolism of clonazepam