Lecture 4 - Brain Neuropeptides Flashcards
What are the seven features of brain NPs?
Synthesised within neurons transported Stored as large dense core vesicles Released by vesicle fusion Receptors are within distinct brain regions Receptor mediated action Behavioural relevance
What is microdialysis?
A method that allows effective monitoring of intracerebral NP release
What are the psychopathologies associated with NPs?
Autism PtSD Borderline Syndrome PPD Depression and Anxiety
List the anxiogenic NPs
CRF
AVP
List the anxiolytic NPs
OXT Prolactin NP 5 CCK-8 NP Y
What does Galanin do?
Stimulate fat intake
What does the NP Orexin do?
Stimulate food intake and sleep
What does the NP leptin do?
Inhibit food intake
What are the roles of oxytocin release in the limbic and hypothalamic areas?
Neuroplasticity Electrical activity stress coping style HPA axis responses Anxiety Maternal behaviour Social preference and social fear Pair bonding aggresson sexual behaviour social cognition maternal aggression
Outline the social preference test
Interaction with occupied cage:Interaction with empty cage
What does acute social defeat before the social preference test cause?
Lack of social preference/social avoidance
What does OXT do to social stress induced social avoidance?
It reverses it
What is the translational value of OXT?
Intranasal OXT reverses negative evaluation of conditioned faces
Male PTSD patients have reduced OXT in their saliva
Low OXTR methylation in patients with social anxiety disorder
What are the effects of intranasal OXT in humans?
trust attractiveness of partner face recognition ethanol withdrawl symptoms social competence
What are the problems with intranasal OXT?
High doses are used in tests
What are the chronic OXT effects on the endogenous systems
Is it uptaken by the brain
