Lecture 33 - Cancer Genetics II Flashcards
1
Q
What pathway is the ras system involved in?
L33 S12
A
Stimulation of cell cycle in response to growth factors and hormones
2
Q
What epigenetic changes are frequently seen in cancer?
L33 S18
A
- hyper and hypomethylation of DNA
- chromatin structure changes
3
Q
What is result of the translocation t(14;18)(q32;q21)?
L33 S25
A
Up-regulation of Bcl-2 which is an anti-apoptotic factor
4
Q
How can viruses cause cancer?
L33 S39
A
They insert near a proto-oncogene and bring a strong promoter that acts on the gene
-or-
They insert in or near a tumor suppressor gene, suppressing it
5
Q
What is Rituximab?
L33 S43
A
Antibody against CD20, a surface protein found on all B cells, that is used to treat lymphoma.
