Lecture 3 - Protein Structure

Question 1

What is the primary structure of protein?

Answer 1

Specific sequence of amino acids

Question 2

What is the model that protein have to follow for proper folding?

Answer 2

The oil drop model, where hydrophobic side chains are in the middle and hydrophilic side chains are in the outside.

Question 3

What are the secondary structure of protein?

Answer 3

Alpha helix and beta pleeted sheats (which are formed through bonds between O and H of the protein backbone)

Question 4

What is the tertiary structure of protein?

Answer 4

Overall conformation of the polypeptide - the spatial organization of the multiple secondary structure elements

Question 5

What are motifs? And name 3

Answer 5

They are combinations of secondary structures forming distinct 3D structure. Coiled-coil motif, Helix-loop-helix motif and zinc finger motif

Question 6

Why do proteins differ from motifs?

Answer 6

Domains are structurally independent entities