Lecture 3 - Non-covalent Interactions 2

Question 1

Is placing non-polar molecules in water energetically unfavorable or favorable?

Answer 1

Unfavorable. Hydrophobic effect. Water surrounding the surface are more restricted in motion.

Question 2

Oil molecules that interact with each other…

Answer 2

Decrease surface area, increase ordered water molecules. Entropically favorable

Question 3

Ice-like

Answer 3

molecules mored in max # of h-bonds, stronger bonds at hydrophobic surface due to reduction in dielectric constant

Question 4

Born-Haber Cycle

Answer 4

Before a ligand can bind to protein, water must be removed