Lecture 3 (Management of T1D) Flashcards
What are the ways you can take insulin via?
syringes
pen needles
continuous subcutaneous insulin infusion (CSII)
Explain basal
beta cells secrete small amounts of insulin throughout the day
Explain bolus
at mealtime, insulin is rapidly released in response to food
What are the categories that fall under bolus?
rapid acting
short acting
List the rapid acting genetic
aspart
glulisine
lispro
faster acting insulin aspart
List the short acting genetic
regular
regular U-500
When is short acting admin?
30-45 prior to meals to cover mealtime glucose excursions
When is regular U-500 used?
it is more concentrated version for those with extreme insulin resistance
When is RAIA administered?
with meals or just prior (15 min) to cover mealtime
What is the timeline for regular?
onset ~30 min
peak ~2-3 hr
DoA ~ 6 hr
What is the timeline for RAIA?
onset ~4-20 min
peak ~0.5-2 hr
DoA ~ 3-5 hr
What are some advantages of RAIA?
more rapid absorption
convenience
better PPG control
lower risk of hypoglycemia
What are some disadvantages of RAIA?
cost more
for the similar effectiveness
What is the caution about some humalog kwikpen?
it can come in 200U/ml instead of 100U/ml so be careful which one
What is the timeline for regular U500?
onset ~15 min
peak ~4-8 hr
DoA ~ 17-24 hr
What is the guideline for the need of U-500?
for those who require > 200 U/d
List the intermediate insulin genetic
neutral protamine hagedorn
What is the major difference to be aware of for intermediate acting?
they are cloudy when all other are clear looking
List the long acting insulin genetic
detemir
glargine (U-100 & U-300)
degludec (U-100 & U-200)
What is the timeline for intermediate?
onset ~1-3 hours
peak ~ 5-8 hrs
DoA up to 18 hr
What is the timeline for long acting?
onset ~90 min
DoA ~ based on type
glargine U100 24hr
glargine U300 >30 hr
degludec 42 h
detemir 16-24 hr
What is the administration of Intermediate?
once or twice daily to provide a background amount of insulin
What is the special prep instructions for intermediate?
since they are in suspension must be hand roll and inverted before used to re-suspend
What is the advantages of LAIA?
peakless
more consistent/less variable BG
less hypoglycemia
What is the disadvantages of LAIA?
cost more for similar efficacy