Lecture 3 - Integrative Omics

Question 1

Mutations affecting specific genes disturbs normal splicing pattern
TRUE OR FALSE

Answer 1

TRUE

e.g. Duchenne Muscular Dystrophy occurs when T to A mutation occurs on Exon31, preventing splicing machinery from correctly interacting, causing Exon31 to be spliced out, causing Duchenne Muscular Dystrophy

Question 2

U1 snRNP:

Answer 2

Binds 5’ splice site of introns

Question 3

U2 snRNP:

Answer 3

Recognises “branch site” and 3’ splice site of introns

Question 4

5’ and 3’ complexes are “bridged” to bring exons together

TRUE OR FALSE

Answer 4

TRUE

Question 5

BLANK bridges factors at 5’ and 3’ splice sites.

Answer 5

STRAP bridges factors at 5’ and 3’ splice sites.