Lecture 3: Addiction (Neurotransmitters and Receptors) Flashcards
1
Q
GABA
A
- inhibitor for NT
- distrbution of mechanisams of reward
2
Q
Dopamine (DA)
A
- main driver of the reward circuit
- VTA –> NA (2nd phase)
- catecholamine
3
Q
Neuroepherine (NE)
A
- main source the LC
- stressed-induced replase
- catecholamine
4
Q
Aceteylcholine (ACh)
A
- centeral to prefrontal cortex circuit (learning/memory)
- receptor on VTA
5
Q
Glutamine (glu)
A
- amino acid
- lsp/lsd plasicity
- cure trigger relapse
6
Q
5-Hydroxytryptamine (5-HT)
A
- main source RN
- line between low HT and impulsistivy (violence in addicts)
- monoamine indole
7
Q
Dopamine Receptors
5 genes (DRD)
A
- G protein-coupled receptors (GPCR)
- seperate functions (pre-synaptic and post-synaptic)
D1 AND D5
(increased cytoplasmic)
D2, D3, AND D4
(decreased cytoplasmic)
8
Q
Animal Behavior Tests Demonstrate The Role Of Dopamine In Addiction
A
- the amount of time spent in drug chamber = drug seeking-behavior
- stimulased environment VTA (preference)
- conditioned place perference
- SELF ADMINISTARTION
- the amount of self admisitration equals the degree of reward experinced
9
Q
Hedonic Tone
A
- base level for dopamine
- tonic dopamine relese = hedonic tone
10
Q
Microdiayalis
A
- measure neuroransmitter in secific nuclei
11
Q
Phasic Tone
A
- addivtive durgs make phasic dopamine levels which fire in the NAc
12
Q
Reward Circuit
A
- decending from anterior to VTA (glutamine driven)
- Decending VTA to NAc (dopamine)
- NAc to Ventral partiall (GABA)
THREE NEUROTRANMITEERS
- dopamine
- glutamine
- GABA
13
Q
Dopamine Is The Neurotransmitter Of Reward
A
- lab animals self administer often to increace the rward circulatory
- voluntary self-administartion and conditioned place preference is produced by intracerebral microinjections of nicotine
- dopamine antagonists are negative reinforcers increase behaviors to reduce administration
