LECTURE 3 Flashcards

1
Q

List the different modes of drug permeation into the body

A

Intracellular junctions
Lipid cell membranes
Transporters
Endocytosis
Exocytosis

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2
Q

How do you order a series of drugs according to their efficiency in passive diffusion?

A

More hydrophobic drugs = more lipophilic
– More efficient at passive diffusion
More hydrophilic drugs = more lipophobic
– Less efficient at passive diffusion

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3
Q

List examples of hydrophilic groups

A

Alcohol
Carboxylic acid
Amine
Ketone
Amide
Ester

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4
Q

Describe hydrophilic groups

A

lipophobic
Typically polar & capable of H-bond formation

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5
Q

Describe hydrophobic groups

A

Lipophilic
Typically, non-polar hydrocarbons

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6
Q

List examples of hydrophobic groups

A

Methyl
Chloro
Phenyl
Hexyl
Cyclohexyl

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7
Q

List common H-bond donors

A
  • OH, - NH
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8
Q

List common H-bond acceptors

A
  • O, - N
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9
Q

What is the effect of protonation in a drug on its solubility in water?

A

Lower water solubility
– neutral or + charged group

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10
Q

What is the effect of deprotonation in a drug on its solubility in water?

A

Higher water solubility
– negatively charged group

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