Lecture 26: Epilepsy & Blackouts Flashcards

1
Q

What can cause a blackout?

A
  • Vasovagal Syncope
  • Hypoxic Seizure
  • Concussive Seizures
  • Cardiac Arrhythmia
  • Non-epileptic attacks
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2
Q

Define and describe Vasovagal syncope/neurocardiogenic and its clinical presentation?

A

FAINTING
Its the body overeacting to certain stimuli such as the sight of blood or extreme emotional distress

  • Light headed
  • Nausea
  • Hot/Sweating
  • Tinnitus
  • Tunnel Vision
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3
Q

What could trigger vasovagal syncope?/neuro-cardiogenic syncope

A
  • Prolonged Standing or standing up too fast
  • Trauma
  • Venepuncture
  • Seeing/experiencing medical procedures
  • Urination
  • Coughing
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4
Q

Whats the difference between a seizure and syncope?

A
  • Syncope tends to happen when your upright
  • Pallor is common in syncope
  • Syncope has a gradual onset vs a sudden onset seizure
  • Injury & incontinence are rare in syncope
  • Recover rapidly from syncope but not seizure
  • Syncope is triggered, precipitants for seizures are rare
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5
Q

How does a hypoxic seizure occur?

A

People who faint and then are kept upright keep fainting and dont breath –> Seizure

Occurs a lot in aircraft where people cant end up lying down

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6
Q

What is a non-epileptic attack?

A

SEizures similar to epilepsy but not caused by electrical activity in the brain.

They are often linked to stress or past abuse

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7
Q

Which gender are more likely to suffer blackouts?

A

Women

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8
Q

When you have a patient who blacked out what do you want to know?

A
  • What they were doing
  • Any warning feelings or Aura
  • Similar previous history
  • Any injury or incontinence
  • How responsive are/were they, what collour did they go, did they move or make sound
  • Whats their pulse like
  • Past medical, psych, alcohol/drug and family history
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9
Q

Investigations for syncope

A
  • Blood Sugar (Cause of fainting)
  • ECG (Cardiac Arrythmias)
  • Consider drugs/alcohol
  • CT head
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10
Q

What features on a first seizure would suggest epilepsy?

A

Primary Generalised Epilepsy:

  • History of myoclonic jerks (particularly in morning)
  • Absences
  • Feeling strange +/- flickering lights

Focal Onset Epilepsy:

  • Deja Vu
  • Rising in abdomen
  • Episodes where they look blank and smack lips
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11
Q

How would you advise someone who’s just had their first seizure?

A
  • Driving Regulations
  • Inquire about employment or potentially dangerous activities
  • Refer to clinic
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12
Q

Define Epilepsy?

A

Neurological disorder where there is an abnormal electrical activity in the brain.

Characterised by:

  • Sudden recurrent episodes of sensory disturbances
  • Convulsions
  • Loss of consciousness
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13
Q

When does epilepsy present?

A

Mainly in infants then its pretty low until the elderly where theres another spike

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14
Q

With what groups is epilepsy more common?

A

People with learning difficulties (22% of people with LD)

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15
Q

What are the classifications of Epilepsy?

A

Primary Generalised Epilepsy (Generally congenital and young)
Focal or Partial Epilepsy (Any age, due to focal brain damage)

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16
Q

What are the types of Primary Generalised Epileptic Seizure

A
  • Tonic Clonic (Tense-Jerky)
  • Myoclonic (Very brief twitch contractions)
  • Clonic
  • Tonic
  • Atonic (Very rapid collapse to floor)
  • Absence (most common in kids, tends to grow out by age 12)
17
Q

How are focal onset seizures different?

A

They vary by which are of the brain is affected

May come with Aura

They may retain awareness/responsiveness (Simple) OR may have impaired awareness (Complex)

Can develop into a secondary generalized seizure
So:
Simple/Complex partial seizures
+/- Secondary Generalisation

18
Q

How does an MRI/EEG change between focal/partial and primary generalized epileptic seizures?

A

An EEG would show generalised vs focal abnormalities in brain function

An MRI or CT may show a physical cause in a focal epileptic but not primary generalised

19
Q

How would you make epilepsy visible in order to test with an EEG?

A

Hyperventilation
Photic Stimulation
Sleep Deprivation

Will show up best in Primary Generalised Epilepsy

20
Q

What other test can be done for epilepsy?

A

Video-Telemetry

Basically an EEG with a camera over several days

21
Q

What are the rules for driving with epilepsy?

A

Normal licenses:

  • Seizure Free for a year Or had seizures but only from sleep.
  • If you have a daytime seizure ever then you will need 3 yrs of none or purely nocturnal seizures

HGV/PSV:
- Seizure and medication free for 10yrs

22
Q

How do we treat Epilepsy?

A

1st line:

  • Sodium Valproate (Anti-convulsant), Lamatrigine, Levetiracetam for Primary Generalised
  • Carbamazepine (Anti-convulsant), Lamatrigine, Levetiracetam for Partial
  • Ethosuximide for Absence seizures

2nd line:

Generalised: Topiramate & Zonisamide

Partial: Swap out and try other anticonvulsants

23
Q

Side effects of Sodium valproate and Carbamezapine?

A

SV:

  • Tremor/Ataxia
  • Weight Gain
  • Hair Loss
  • Pancreatitis/Hepatitis

Carbamazepine:

  • Ataxia
  • Low Serum Na
  • Severe Skin rash
  • Nystagmus/Blurred Vision
24
Q

What is Status Epilepticus?

A

A prolonged or Recurrent seizure that lasts for >5mins with no recovery period in between

(Most common type is TCSE - Tonic Clonic Status Epilepticus)

Usually caused by stroke, tumour, haemorrhage or alcohol and 90% of deaths are due to the underlying cause not the seizure itself

Can lead to neuro problems (brain damage) in children

25
Q

How do we treat TCSE?

A

1st line - Lorazepam (Benzodiazepines)
2nd line - Valproate
3rd line - Anaesthesia e.g. propofol

26
Q

What is Carbamazepine also used for?

A

As well as being an anticonvulsant it treats nerve pain in conditions such as Trigeminal Neuralgia