Lecture 23.2: COVID

Question 1

What is the disease progression fo COVID?

Answer 1

• Stage I: Early Infection [HIGHEST viral response]
• Stage II: Pulmonary [LOWEST viral and inflammatory]
• Stage III: Hyperinflammation [HIGEST inflammatin response]

Stage I is normal 7 day?

Question 2

Within the Infectious Disease Society of America Guidelines, when should you use and not use Glucocrticoids?

Answer 2

• Recommends: Dexamethasone for critically ill
• Suggests: Dexamethasone for severe, but non-critical
• Sugguest against Dexamethasone for mild-to-mod COVID`

Question 3

Within the Infectious Disease Society of America Guidelines, when should you use and not use Inhaled Corticosteroids?

Answer 3

• Suggest Against

Question 4

Within the Infectious Disease Society of America Guidelines, when should you use and not use Interleukin 6 Inhibitor?

Answer 4

• Suggest: Tocilizumab for Severe or critical COVID with inflammation
• Suggest: Sarilumab when Tocilizumab not available

Question 5

Within the Infectious Disease Society of America Guidelines, when should you use and not use Remdesivir?

Answer 5

• Suggests: For mild-mod; initiated Within 7 days of symptoms

Question 6

What is Remdesivir?

Answer 6

• PRODRUG
• MOA: Interferes with viral RNA-dependent RNA Poly; delayed chain rerminatino of viral RNA transcription

Question 7

What is important to know about the safety of Remdesivir?

Answer 7

• Sulfobutylether-beta cyclodextrin [SBECD]

Question 8

Within the Infectious Disease Society of America Guidelines, when should you use and not use Baricitinib?

Answer 8

• Suggest: Severe COVID with cortocsteroids rather than no baricitinib

Question 9

Within the Infectious Disease Society of America Guidelines, when should you use and not use Nirmatrelvir/Ritonavir [Paxlovid]?

Answer 9

• Suggest: mild-mod; initiated Within 5 days of symptoms

NO significant decrease in mortality

Question 10

Within the Infectious Disease Society of America Guidelines, when should you use and not use Molnupiravir?

Answer 10

• Suggest: mild-mod; initiated within 5 days o symptoms