Lecture 23

Question 1

Papillomavirus

Answer 1

Non- enveloped double stranded circular DNA

Question 2

polyomavirus

Answer 2

Non- enveloped double stranded circular DNA

Question 3

Papillomavirus

Answer 3

HPV’s

Warts and cancer

Question 4

polyomavirus

Answer 4

BK JC virus

simian virus 40 - SV 40

Question 5

HPV

Answer 5

16 and 18 most common
E6 and E7 are oncogenes
Bind and inactivate cellular growth suppresors
P53 bound by E6 
P105 bound by E7

Question 6

HPV

Answer 6

transmitted on fomites

Question 7

HPV vaccine

Answer 7

gardacil and cervarix
protects against HPV 16, 18, 31, 45
Also HPV 6, 11

Question 8

HPV warts

Answer 8

most common HPV 1-4

Anogenital warts HPV 6 and 11

Question 9

HPV benign head and neck tumors

Answer 9

oral papillomas

laryngeal papillomas HPV 6 and 11

Question 10

Gardasil

Answer 10

contains L1 of HPVs 6, 11, 16, 18

Question 11

Polyomavirus

Answer 11

human polyomavirus BK and JC don’t usually cause disease
SV40 virus
- tumor causing virus
- not human disease

Question 12

Polyomavirus - treatment

Answer 12

cidofovir

side effect can be nephrotoxic

Question 13

Adenovirus

Answer 13

respiratory tract infection
conjunctivitis
hemorrhagic cystitis
gastroenteritis 
used for DNA delivery

Question 14

Adenovirus

Answer 14

tough virus spread by fecal-oral, aerosol, fingers, fomites, swimming pools
human to human
five to ten percent pediatric respiratory cases
types 1,2,5,6

Question 15

Adenovirus gene therapy

Answer 15

correction of the normal genes

inactivation of E1, 2, 4 replaced by gene of interest

Question 16

Small pox virus

Answer 16

category A agent
largest virus
contains its own RNA polymerase
enveloped with core
uncoatase (eprotein)
Linear DNA fused at both ends

Question 17

Small Pox patho

Answer 17

replicates in upper respiratory tract