Lecture 2.1: Lymphoma and Leukemia - Pediatrics Flashcards
What is the leading cause of death by disease past infancy among children in the United States?
Cancer
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What is the most common types of cancer diagnosed in chidlren ages 0-14 y/o in the US?
Leukemias
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What is the most common types of cancer diagnosed in adolescents 15-19 y/o; what is a common infectious agent implicated?
Lymphomas; EBV
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Which type of lymphoma is the most common malignancy in age group 15-19 y/o?
Hodgkin lymohoma
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What are B-symptoms?
- Unexplained fever 39°C
- Wt. loss >10% total BW over 6 months
- Drenching night sweats
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Any pt with persistent, unexplained LAD unassociated with an obvious underlying inflammatory or infectious process should get what?
A CXR to rule of mediastinal mass before undergoing LN biopsy
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What are the clinical manifestations of Wiscott-Aldrich Syndrome; how is it inherited; what is it a risk factor for?
- X-linked recessive
- Recurrent sino-pulmonary and ear infections
- Severe atopic dermatitis
- Bleeding –> 2’ to significant thrombocytopenia
- Risk factor for NHL***
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Burkitt lymphoma commonly manifests in pediatric populations how?
- Abdominal (sporadic type)
or
- Head and neck dz (endemic type) w/ involvement of BM or CNS
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Which genetic trisomy associated with both ALL and AML?
Trisomy 21
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Which type of leukemia constitutes 97% of all childhood leukemias?
Acute leukemia
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