Lecture 2: The Neuron, Synaptic Transmission and Neurotransmission Flashcards

1
Q

What functions do the brain stem regulate?

What are the different components of the brain stem?

A

Lower level functioning: Respiration, blood pressure, heart rate, GI functioning, states of sleep/wakefulness, behavioral alerting, attention, arousal

Cerebellum, pons, medulla oblongata

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2
Q

What are the different lobes in the brain/where roughly are they located?

A

Frontal - front
Parietal - the difference
Occipital - back
Temporal - side

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3
Q

Name 2 areas of the brain that are of special interest? what are their functions?

A

Area of Wernicke - sensory/speech

Area of Broca - motor/speech

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4
Q

How are humans distinguished from other animals in terms of brain development?

A

The brain expands as the skull recedes - to compensate for lack of space, the brain develops convolutions

Convolutions - fissures/folds that increase amount of space for brain to grow

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5
Q

What part of the brain runs along the center and creates (not joins) hemispheres?

A

Longitudinal fissure

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6
Q

What/where are the 3 gyrus components?

What is located in the central sulcus?

A

Precentral gyrus - front
Postcentral gyrus - back
Central sulcus - splits gyruses
1. Somatosensory cortex - responsible for encoding our rep of parts of ourselves and sensations

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7
Q

What are the functions/location of the frontal lobe? What are the hemispheric differences?

A
Front of central sulcus 
Motor functions, memory, language, emotion 
Hemispheric diff 
1. left - language and related movement 
2. right - non-verbal movement 
Prone to injury
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8
Q

What are the functions/location of the parietal lobe?

A

Behind central sulcus
Body information, touch, muscle-stretch
Somatosensory representation: homunculus - body function, body information, rep of ourselves and how we engage with the environment externally

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9
Q

What are the functions/location of the occipital lobe?

A

Located in the posterior of the cortex

Visual area

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10
Q

What is significant about phineas gage?

A

underwent severe waking trauma to frontal lobe - resulted in massive personality shift: mood swings, movement issues, incapable of expressing emotions

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11
Q

How many neurons in the brain? What do neurons do/maintain/what is this called?

A

At least 100 billion neurons
Cells specialized dor signal transmission - exchanging info
Neurons maintain electric charge - signals pass down the length of a neuron = saltatory conduction

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12
Q

What are the structures in a neuron? what are their functions?

A
Axon terminals - transmitters, send to others 
Shwan's cells - makes myelin 
Axon - conducting fiber 
Node ranvier - spaces 
Myelin sheath - insulating fatty layer than speeds transmission by skipping node 2 node 
Dendrites - receivers, take from others 
Cell body 
Nucleus
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13
Q

Describe a neuronal membrane
What is an electrical gradient?
What is a chemical gradient?

A

Selective permeability
Ions - sodium (Na outside cell, forces in) + potassium (K - inside cell, forces out)
More of one ion on one side than the other - both have positive charge (inside less so tho)

E - more posi outside than in negi
C - more Na than K ouside

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14
Q

What is saltatory conduction?

A

Process of signal jumping from Rnode to Rnode - happens at p.1 and the wave is carry through
High concentration of Na outside causes the ions to go inside
K then travels from inside to outside
Repolarization occurs afterwards

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15
Q

What is a synapses? synaptic cleft?

What is a simple neural network? a complex?

A

Neurons don’t touch

  1. Junction between two or more neurons - includes pre-synaptic and post-synaptic sides
  2. Space between the neurons
  3. 3 neurons communicating
  4. many neurons binding to a cell (ex: retinal ganglion cell)
    Innervation = number of connections
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16
Q

What is the structure of a synapses

A

Presynaptic - axon, mitochondrion (inside), synaptic vesicle
Postsynaptic - dendrite, receptor site
Between = synaptic gap and neurotransmitters

17
Q

What are the simple steps of receiving an action potential?

A
  1. synthesis
  2. storage in vesicles
  3. release, dumping contents
  4. postsynaptic effects
  5. inactivation, reuptake (recycled)
18
Q

What are the necessary criteria for neurotransmission?

A
  1. substance must be present within the presynaptic neuron
  2. substance must be released in response to presynaptic depolarization, and release must be Ca2+ dependent
  3. specific receptors or the substances must be present on the postsynaptic side
19
Q

Define depolarization

Define repolarization

A

Neuron is more likely to fire an action potential - movement of cell membrane potential to more positive value, influx of Na ions

Return to neutral, potassium gates open

20
Q

Name the four neuroT types? examples?

A

Catecholamines - dopamine, norepinephrine, epinephrine/adrenaline
Excitatory - glutamate (ndma, ampa, kainate)
Inhibitory - GABA (ABC tons in between)