Lecture 2 - Cell death Flashcards
1
Q
TNF: what is it and what does it do?
A
Tumour necrosis factor receptor
Trimeric transmembrane receptors that bind a variety of extracellular ligands that induce a range of cell responses
2
Q
A
Caspase-9 uses the CARD domain to bind to oligomeric APAF-1.
Caspase-8 activation uses two different binding domains, the DEATH
DOMAIN and the DEATH EFFECTOR DOMAIN.
3
Q
A
Activation of Fas (CD95) by FasL presented on cytotoxic T-cells - the prototype Death Receptor
