Lecture 2

Question 1

Increasing cognitive and function impairment

Answer 1

Alzheimers Disease

Question 2

Accumulation of Plaque

Answer 2

Alzheimers Disease

Question 3

Disease Symptoms are memory problems, troublesome behaviors and activities of daily living suffer

Answer 3

Alzheimers Disease

Question 4

If 1st degree relative has Alzheimers Disease, what is the lifetime risk of relative?

Answer 4

30%

Question 5

T/F; less than 1% of Alzheimers Disease is inherited as monogenic disease?

Answer 5

True

Question 6

Majority of Alzheimers Disease are ____ disease

Answer 6

Multifactorial

Question 7

What is presenilin?

Answer 7

Protein that plays a role in generation of amyloid beta from amyloid precursor protein.

Question 8

What is the APP Gene?

Answer 8

Amyloid precursor protein

Question 9

The earliest onset of Alzheimers Disease is found in which gene?

Answer 9

Presenilin 1

Question 10

A membrane protein that sits on the membrane and extends outward?

Answer 10

Amyloid Precursor Protein

Question 11

What does a secretase do in Alzheimers Disease?

Answer 11

Cuts Beta Amyloid

Question 12

What protein forms the sticky plaques that create Alzheimers Disease?

Answer 12

Beta-Amyloid Plaque

Question 13

Part of the gamma- secretase complexes, which snips fragments of amyloid precursor protein (APP), releasing B-amyloid peptide into the extracellular space where it forms plaques?

Answer 13

Presenilin