Lecture 2

Question 1

What is pharmaceutics?

Answer 1

Process of turning an NCE into a medication that can be safely and effectively used by patients. Also named science of dosage from design.

Question 2

Definition of medicine?

Answer 2

Drug delivery system that can administer drugs in a safe, efficient, accurate, reproducible and reproductive manner.

Question 3

Factors impacting dosage from design? (3)

Answer 3

1. Physiochemical properties (Pka)
2. Biopharmaceutical considerations (how administration route of dosage affects rate and extent of drug absorption)
3. Therapeutic considerations e.g patient population

Question 4

Dosage forms for administration routes? (ORTPRNEE)

Answer 4

Oral, rectal, topical, parentetal, respiratory, nasal, eye, ear.

Question 5

Variation of onset times for action of different dosage forms?

Answer 5

1. Seconds: intravenous injections
2. Minutes/hours: intramuscular/subcutaneous injection, buccal tablets
3. Several hours: enteric coated tablets
4. Days - weeks: implants/depo injections

Question 6

Basic legal classification of drugs?

Answer 6

1. POM’S: prescription only medicines
2. P: without prescription, under supervision of a pharmacist
3. GSL: general sale, no supervision