lecture 2

Question 1

type two hypersensitivity mediated by what antigen?

Answer 1

IgM and IgG

Question 2

type 1 hypersenstivity mediated by?

Answer 2

IgE

Question 3

type 3 hypersensitivity mediated by

Answer 3

soluble antibodies that forms immune complex

Question 4

type 4 hypersensitive mediated by

Answer 4

T lymphocyte mediated or delayed NOT ANTIBODY!!!

Question 5

common causes of hypersensitivy reactions
for: 
type 1
type 2
type 3 
type 4

Answer 5

type 1:plant pollens, mold spores, feces of very small animals; ingested materials: food, orally administered drugs;
Type 1 and 3: injected materials: insect venoms, vaccines, drugs, therapeutic proteins;
ingested materials;
Type 4: contacted materials: (example: poison ivy, synthetic chemicals, metals)

Question 6

to get type 1 HSR need?

Answer 6

Th-2 cells needed, IL-4 and IL-13 promote isotype switching from IgM to IgE. (NEED IgE)

Question 7

non cytosotic type 2 HSR

Answer 7

change function of cell but dont kill

Question 8

antigen that gives rise to allergic response?

Answer 8

allergen

Question 9

allergic response?

Answer 9

overexuberance of reaction of a innoculus immune response

Question 10

anaphylaxis

Answer 10

serious allergic reaction. can cause to go into shock, bp drops suddenly and airways narrow

Question 11

generic factors contribute to development of what allergec disease?

Answer 11

IgE mediated response

Question 12

genetic polymorphysms

Answer 12

MHC2 antigen presentation, extrelly polymorphic
TLR: activation determines response
cytokine : linked to qunatitive response (mostly type 4)

Question 13

tim gene family

Answer 13

expressed in Th 1 and 2 cells, change function

Question 14

IL-4

Answer 14

isotype switchin to Th2

Question 15

hygine hypotheiss

Answer 15

early exposure to antigens wil result in lack of type 2 response, no isotype switching which is necessary to type 1 HSR response

Question 16

hygine hypotheiss

Answer 16

early exposure to antigens wil result in lack of type 2 response, no isotype switching which is necessary to type 1 HSR response