Lecture 2 Flashcards
1
Q
What catalysts are used in alkene metathesis?
A
Grubbs or Schrock
- Ru catalysts more stable but less reactive
- Mo often requires a glove box
2
Q
What are the challenges of alkene metathesis?
A
- Mixture of cis and trans products
- some steps being reversible
Develop a more complex catalyst to allow selectivity
3
Q
What is one requirement for alkyne metathesis and why?
A
- Alkynes need terminal Me groups
- Prevent insertion into a carbon hydrogen bond to form a vinyl species
4
Q
How do you achieve specific alkene orientation in enyne metathesis?
A
- react alkynes and then selectively reduce the products
