lecture 2

Question 1

Wound Healing cascade: HEMOSTATSIS

Answer 1

• Platelet activation
• activation of clotting cascade
• complement cascade
• release of chemicals that promote inflammations

Question 2

Main function Hemostasis?

Answer 2

Coagulation and secretion of growth factors

Question 3

Inflammatory stage

Answer 3

Vascular stage: 
Hyperemia  
Five cardinal signs of inflammation
Exudate stage:
Serous
Purulent
Fibrinous
Hemorrhagic 
Reparative stage: 
Phagocytosis with true wound healing beginning
MAIN FUNCTION: REMOVE DEBRIS

Question 4

5 signs of inflammation

Answer 4

pain, redness, heat,

Question 5

Proliferative Healing

Answer 5

Overlaps with inflammatory phase
Granulation
Angiogenesis
Contraction
Epithelialization
From edges to center of wound 

Main function: Fibroblasts produce collagen and epithelial tissue covers the wound
“Fill and Cover”

Question 6

Remodeling phase

Answer 6

Overlaps with proliferative phase

Organization of collagen tissue into more definitive and finite pattern

Increase in tensile strength (scar tissue)
Scar tissue is only 80% as strong

3 weeks to 2 years

Main function: remodeling of tissue and increasing its tensile strength

Question 7

Healing by Primary Intention

Answer 7

-Edges brought together and held there by mechanical means
-Preferred method of healing
-Healing begins within 2-3 days
Benefits?(less scaring, decrease risk for infection, decrease healing time)

Question 8

Healing by Secondary Intention

Answer 8

Gradual filling of the wound with granulation tissue
Large surface areas with retracted edges or when large amounts of tissue have been lost

Cons? (slow healing, increase infection risk)