Lecture 2

Question 1

Bioavailability

Answer 1

How much free drug there is in your system to exert its effects

Question 2

Steps of pharmacokinetic

Answer 2

Absorption
Distribution
Metabolism
Excretion

Question 3

Routes of administration

Answer 3

Inhalation, oral (PO), transdermal (cream, bc, patches), transmucosal,injection

Question 4

What is the main difference between oral administration and other forms of administrations

Answer 4

Goes through first pass metabolism

Question 5

Examples of transmucosal

Answer 5

Sublingual/ buccal (between gums and cheeks)
Rectal
Intranasal
Intraocular
Vaginal
Urethral

Question 6

Different types of injection

Answer 6

Subcutaneous ( under the skin)
Intramuscular
Intravenous

Question 7

Drugs injected subcutaneously

Answer 7

Vaccines, insulin, growth hormones

Question 8

Subcutaneous injections are

Answer 8

Slowly released and steady

Question 9

Intramuscular injections are

Answer 9

Absorbed quicker than subcutaneous but slower than intravenous

Question 10

Intravenous injections are

Answer 10

Absorbed quickly, accurate

Question 11

What is cytochrome p450

Answer 11

Family of enzymes responsible for metabolism of many psychoactive drugs

Question 12

Examples of modification

Answer 12

Induction by repeated use
Inhibition by other drugs or foods
Competition between drugs

Question 13

What is co-metabolism

Answer 13

When two drugs do not compete to be broken down but will combine and make a new drug

Ex: cocaethylene (alcohol and cocaine)

Question 14

How can drugs be excreted

Answer 14

Urine, seat, saliva, feces