Lecture 18 - The Pentose Phosphate Shunt Flashcards
1
Q
What is one purpose of the PPS?
A
Ribose-5-phosphate is needed for nucleotide synthesis
2
Q
What is another purpose of the PPS?
A
NADPH is needed to reduce glutathione, to synthesize fatty acids, nitric oxide, and steroids/sterols to detoxify drugs (cytochrome P450), and as part of the respiratory burst
3
Q
How many NADPH molecules do you make per G6P that you start with?
A
2
4
Q
How many carbons does transketolase move and what does it use to do that?
A
2 carbons and it uses thiamine
5
Q
How many carbons does transaldolase move?
A
3 carbons
6
Q
What diseases are associated with a thiamine deficiency?
A
Wernicke-Korsakoff
Beri-beri (dry and wet)
