Lecture 18 Flashcards
What is antibody-dependent enhancement of infection?
It occurs when preexisting antibodies from a primary dengue virus infection bind to an infecting dengue virus particle during a subsequent infection with a different serotype.
What happens to the antibodies from the primary dengue infection during a subsequent infection?
The antibodies cannot neutralize the virus.
What do the antibodies bind to during a subsequent dengue infection?
They bind to receptors called Fcγ receptors (FcγR) on circulating monocytes.
What is the effect of the Ab–virus complex on monocytes?
It helps the virus infect monocytes more efficiently.
What is the outcome of antibody-dependent enhancement of dengue infection?
An increase in overall replication of the virus and a higher risk of severe dengue.
Fill in the blank: Antibody-dependent enhancement occurs during subsequent infection with a different dengue _______.
[serotype]
What is antibody-dependent enhancement of infection?
Occurs when preexisting antibodies bind to an infecting dengue virus particle during a subsequent infection with a different serotype
What happens to antibodies from a primary dengue virus infection during a subsequent infection?
They cannot neutralize the virus but form an Ab–virus complex
What are Fcγ receptors (FcγR)?
Receptors on circulating monocytes that the Ab–virus complex attaches to
What is the effect of antibodies on monocyte infection efficiency?
They help the virus infect monocytes more efficiently
What is the outcome of antibody-dependent enhancement of dengue infection?
Increase in overall replication of the virus and a higher risk of severe dengue
Fill in the blank: Antibody-dependent enhancement of dengue infection occurs during a subsequent infection with a _______.
[different dengue serotype]
True or False: The antibodies from the primary dengue infection can neutralize the virus during a subsequent infection.
False
