Lecture 17: Integration salt and water balance 2

Question 1

Where is aldosterone released from?

What causes release?

Answer 1

• Cortex of adrenal gland
• Causes of release:
  
  • Angiotensin II
  • high K+

Question 2

what does aldosterone do in the kidney?

Answer 2

• Binds to mineral corticoid receptor which –> insertion of ENaC in the lumen membrane of principal cells –> increased Na+ reabsorption into cell –> increased Na+ pushed into renal interstitial fluid by Na/K pump

Question 3

What drug blocks aldosterone?

Answer 3

• Spironolactone

Question 4

What factors inhibit Na+ reabsorbtion?

Answer 4

• ANP
  
  • Released from atria in response to increased stretch
  • Binds to receptors to increase cGMP
  • Blocks ENaC and inhibits sodium potassium ATPase
    
    • Stops RAAS pathway

Question 5

DRAW FLOW CHARTS FOR:

• Decreased BV & Decreased BP
• Increased BV & Increased BV
• Decreased osmolarity
• Increased Osmolarity