lecture 16 Flashcards
list the function of prolactin
- growth and lactogenesis in mammary glands during pregnancy
- inhibits fertility
- differentiation of hair cells (coat changes)
describe the hypothalamic releasing hormone for prolactin (name + function)
- no specific stimulatory hypothalamic hormone: BUT secretion is increased by thyrotropin releasing hormone (TRH) and vasoactive intestinal peptide (VIP) (VIP increased during infant suckling)
- dopamine inhibits secretion of prolactin (secreted by arcuate nucleus + binds inhibitory D2 receptors on lactotrophs)
describe the ant pit hormone (cells, hormone, target)
- lactotrophs
- prolactin
- mammary glands, gonads, hair cells
describe the rate of secretion of prolactin
pulsatile
- increases w/ pregnancy, chest wall stim (suckling), trauma
describe prolactin during pregnancy
- levels build up during pregnancy but milk secretion DOES NOT begin until after birth (why?)
- lactation inhibited by high estrogen and progesterone during preg
- prolactin is released into mother’s blood stream during infant suckling causing an increase in milk production
describe the mechanism of increased prolactin that leads to decrease fertility
- increased prolactin during lactation and breastfeeding help suppress ovulation
- high level prolactin inhibits GnRH > decreased fertility
what are the effects of pituitary tumors?
lead to elevated levels of prolactin
> hyperprolactinemia
= amenorrhea + male infertility (absence of menstruation + inhibition of testosterone and sperm production)
how is prolactinoma treated?
- w/ dopamine agonist = bromocriptine
describe the hypothalamic output to posterior pituitary
- comprised of axonal projections from magnocellular neurons with cell bodies located in hypothalamus (PVN and SON)
- activation of hypoth neurons causes release of hormones directly into general circulation (axonally transported to posterior pit)
describe the effects of oxytocin (response to + effects)
- released in response to:
- birth of an offspring (stimulate uterine contractions during and after birth)
- stim of mammary glands (causes milk let down)
describe the oxytocin receptor
GPCR > Gq > increase intra cal levels
describe oxytocin during birth
- stim contractions of smooth muscles
- SM cells of uterus increase expression of oxytocin R during gestation = increased estrogen (binds transcription factor R in target tissue) > increase OT R expr
- oxy binds during labor > contractions of SM of uterus
describe oxytocin treatment during labor and birth + maternal
- oxytocin analogs (pitocin) facilitates labor and delivery
- facilitates the establishment of maternal behaviors ie increases nurturing behaviors in lactating females > attachment to offspring = important for survival
describe effects of oxytocin on mammary glands
- stimulate milk ejection from alveoli (lined with SM cells called myoepithelial that expresses OT R)
- binding > contraction > milk ejection
vasopressin effects + in response to
- stimulate conservation of water primary effect = ADH increase plasma osmolarity (in response to increased plasma osmolarity increase BV > support blood pressure)
- decrease in BP (causes vasoconstriction = secondary effect = very high levels of vasopressin release ie severe hemorrhage)