Lecture 16 Flashcards
How was the ER formed?
Likely invagination of the membrane around the ancient prokaryotic bacteria.
What are the two forms of ER?
Smooth ER and Rough ER
What ion does the ER store ?
Intracellular Ca2+
What are two (2) important functions of the ER?
Production of most transmembrane proteins and lipids for organelles, and makes most proteins destined for secretion out of the cell. (Lumen, Golgi, or Lysosomes)
What gives the Rough ER its rough appearance?
Ribosomes on the outer surface
What is the structure within the ER?
The Lumen
Where are proteins made that enter the ER?
At the surface of the ER
What functions are done specifically at the rough ER?
Protein production and modification, Lipid synthesis
What four(4) functions are done specifically at the smooth ER?
Intracellular Ca2+ storage, lipid metabolism, production of lipoprotein particles (carrying lipids via bloodstream to other parts of body, and detoxification of lipid soluble drugs and other harmful products (cytochrome p450)
What enables drugs to move into cells?
Their hydrophobic properties
How are proteins imported in the ER?
Either co-translationally translocation or post-translationally translocation
What makes up the signal recognition protein?
RNA and protein
What mediates the importation of proteins into the ER?
Signal recognition particle
How was the Golgi discovered?
stained nervous tissue w/ metallic impregnations in a method called the “black reaction”
When were golgis first discovered, then when were they confirmed to be an organelle?
1898, and 1950
