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HEMA 2 > Lecture > Flashcards

Lecture Flashcards

1
Q

Controlled by vessel Smooth Muscle, enhanced by chemicals, secreted by platelets

A

Vasoconstriction

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2
Q

To exposed subendothelial connective tissue

A

Platelet Adhesion

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3
Q

Interaction and adhesion of platelets to one another to form initial plug at the site of injury

A

Platelet Aggregation

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4
Q

Coagulation factors interact on platelet surface to produce fibrin

A

Fibrin-Platelet Plug Formation

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5
Q

Fibrin clot must be stabilized by coagulation factor XIII

A

Fibrin Stabilization

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6
Q

What are the Primary Phase of Homeostasis??

A

Vasoconstriction
Platelet Adhesion
Platelet Aggregation

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7
Q

What are the Secondary Phase of Homeostasis??

A

Fibrin-Platelet Plug Formation
Fibrin Stabilization

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8
Q

Physiological Response that is/are included in Neuro-Muscular Response

A

Vasocontriction

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9
Q

Physiological Response that is/are included in Platelet Activation

A

Adhesion release
Reaction Aggregation

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10
Q

Physiological Response that is/are included in Coagulation

A

Intrinsic PW
Extrinsic PW
Common PW

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11
Q

Physiological Response that is/are included in Fibrinolysis

A

Plasminogen
Tissue Plasmin Activator
Plasmin

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12
Q

What type of Blood Vessel is for metabolic exchanges to diffusion?

A

Capillaries

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13
Q

What Blood Vessel is “oxygenated”?

A

Arteries

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14
Q

What Blood Vessel is “deoxygenated” to valves?

A

Veins

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15
Q

How many hours that Veins consume in valves?

A

8 hours

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16
Q

What substance that inhibits platelet adhesion and aggregation and stimulates vasodilation?

A

Prostacyclin (Prostaglandin I2)

17
Q

What substance is only stimulates vasodilation?

A

Adenosine
(Metabolic product of ATP to ADP)

18
Q

What substance that destroy ADP and limits the platelet activation?

A

ADPase

19
Q

What substance that has endothelial Cell Receptor for thrombin?

A

Thrombomodulin

20
Q

What substance that binds and inactivates thrombin and enhances anticoagulant and fibrinolytic action of Protein C found in the plasma?

A

Thrombomodulin

21
Q

A substance that has an action that coats the endothelial cell surface and weakly enhances the activity of antithrombin III

A

Heparan sulfate

22
Q

A substance that has an action of Plasma Anticoagulant

A

Heparan Sulfate

23
Q

A substance that converts Plasminogen to Plasmin

A

Tissue Plasminogen Activator

24
Q

A substance that is released only on appropriate stimulus, such as vessel injury, to prevent excessive clot formation.

A

Tissue Plasminogen Activator

25
Q

A substance that has regulatory protein for fibrinolytic system

A

Plasminogen Activator Inhibitor-1

26
Q

A substance that protein produced in endothelium and stored in subendothelium (in the form of Weibel-Palade bodies) before secretion into the plasma and attachment to factor VIII: C

A

Von Willebrand Factor (vWF)

27
Q

It is a cytoplasmic fragments of the megakaryocytes

A

Platelets

28
Q

What are the functions of platelets in hemostasis?

A
  1. Adhesion to injured vessels
  2. Aggregation at the site of the injury site
  3. Promotion of Coagulation on their Phospholipid surface
  4. Release of biochemicals important to hemostasis from their alpha and dense bodies
  5. Induce clot retraction
29
Q

What are the Dense Granules?

A

ADP
Calcium
Serotonin

30
Q

What are the Membrane Phospholipids?

A

Thromboxane A2 Precursor

31
Q

Endoreduplication is regulated by what gene?

A

RUNX-1

32
Q

Progressive nuclear lobulation, includes DNA content, without cytoplasmic division.

A

Polyploidization

33
Q

What are the Factors Influencing Megakaryopoiesis?

A

•Early Acting Multilineage cytokines
•More Specific Cytokines

34
Q

What are the Terminal Megakaryocyte Differentiation Stages?

A

Morpholigically recognizable
Wright-stained Bone Marrow aspirate
Hematoxylin & Eosin Bone Marrow biopsy

35
Q

MK-I is also known as

A

Megakaryoblast

36
Q

Promegakaryocyte is also known as

A

MK-II

37
Q

MK-III is also known as

A

Megakaryocyte

HEMA 2 (1 decks)

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