Lecture 15 long acting implants Flashcards
Describe the benefits of long-acting implants in terms of patient compliance and therapeutic outcomes.
Long-acting implants improve patient compliance by reducing dosing frequency, enhancing adherence to treatment regimens, and leading to better therapeutic outcomes.
What is the primary advantage of sustained drug delivery through long-acting implants?
Sustained drug delivery through long-acting implants involves controlled release of medication over extended periods, maintaining stable plasma levels, and minimizing fluctuations in drug concentration.
How do long-acting implants contribute to reducing healthcare burden?
Long-acting implants reduce healthcare burden by eliminating the need for frequent injections or daily medication intake, thus lessening the burden on healthcare systems and patients while improving efficiency and quality of care.
Define monolithic devices in the context of long-acting implants.
Monolithic devices are single, solid pieces of material that contain the drug of interest, offering simple manufacturing through moulding, flexibility in material usage, and a release mechanism involving diffusion of the drug from the implant core or erosion if the polymer is biodegradable.
Describe the potential benefits of tailored treatment options provided by long-acting implants.
Long-acting implants offer tailored treatment options by allowing customization to deliver specific drugs at predetermined rates, providing personalized treatment for various chronic conditions and therapeutic needs, and expanding the range of therapeutic options available to clinicians.
How do long-acting implants contribute to better disease management?
Long-acting implants improve disease management by providing consistent and effective drug delivery, better control of symptoms, prevention of disease progression, and expanding the range of therapeutic options available to clinicians.
Explain the process of drug release in monolithic long-acting implants and their benefits
In monolithic long-acting implants, the drug is released through diffusion from the implant core and by erosion if the polymer is biodegradable. These implants offer flexible size and shape, easy sterilization, but require surgical collocation and removal, being one of the most common types on the market.
Describe a reservoir system for delivery.
A reservoir system consists of a reservoir enclosed in aocompatible shell or membrane, allowing drug release through diffusion across the membrane. It can be a separate compartment or porous matrix within an implant.
Describe refillable implants.
Refillable implants are solid devices made of metals or resistant polymers that can be implanted subcutaneously. They contain one or more chambers for loading and releasing active substances, with a release mechanism typically covered by a membrane.
How can refillable implants be refilled?
Refillable implants can be refilled using conventional hypodermic syringes and needles.
Define Nexplanon.
Nexplanon is a subcutaneous implant for contraception that can last up to 3 years. It is made of a biocompatible material called PEVA.
What are the advantages of PEVA in Nexplanon implants?
PEVA in Nexplanon implants offers biocompatibility, controlled drug release, flexibility, durability, radiopacity for visibility under X-ray imaging, ease of manufacturing, and non-biodegradability.
Describe the Ocusert ocular implant.
Ocusert is an ocular implant placed under the eyelid for controlled drug release, particularly used for managing glaucoma. It releases the drug for up to one week, improving patient compliance.
What is the purpose of using PEVA in Nexplanon implants?
PEVA in Nexplanon implants is used for its biocompatibility, controlled drug release, flexibility, durability, radiopacity, ease of manufacturing, and non-biodegradability properties.
Describe the Dextenza® ocular implant.
Dextenza® is an intracanalicular insert containing Dexamethasone, released to the eye’s surface for 30 days to manage post-surgical inflammation.
