Lecture 15 Flashcards
Malaria
caused by 4 species of Plasmodium
Plasmodium flaciparum
transmitted by bite of infected Anopheles
causes: chills, fever, anemia, hypertrophy (increase in size) of liver and spleen
control: wetland drainage, insecticides, bed netting
treatment
- chloroquine: block heme polymerization
- malarone: blocks transport and pyrimidine synthesis; causes crazy dreams
no vaccines
fungi
spores mycellium hyphae multicellular: mold unicellular: yeast cell wall made of chitin domain: eukarya; kingdom: fungi monophyletic
fungi nutrition
saprophytes: live on dead organic matter
absorptive: secrete enzymes then absorb nutrients
fungi: decomposers
breakdown complex organic compounds including cellulose
mycology
study of fungi
mycoses
disease caused by fungi
mycotoxicosis
poisoning by fungi toxin
aflatoxins: intercalate into DNA
- produced by aspergillus
ergot alkaloids: causes delusions and convulsions
fungi: distribution
mostly terrestrial can be pathogen can be part of human microflora can form beneficial associations - mycorrhizal fungi mutualism with plant roots - lichens: fungi + cyanobacteria
Yeast
unicellular
Saccharomyces cerevisiae: bread, beer, wine
Candida albicans: microflora of mouth, vagina, and intestinal track
fungi sexual production
fusion can create single hypha
distinct nuclei - dikaryon
nuclei can fuse forming diploid zygote
meiosis form haploid spores
Chytridiomycota
simplest fungi
aquatic
motile flagellated zoospore
chytridiomycosis: massive frog deaths
zygomycota
sexual zygospores, asexual sporangiospores
ex. Rhizopus
bread mold
meat tenderizer, birth control agent
ascomycota
sac fungi- ascus
sexual ascospores; asexual conidiospores (airborne dispersal)
ex. Saccharomyces, Aspergillus, Penicillium, and Cladosporium
Basidiomycota
club fungi
basidium: bears sexual basidospores
ex. mushrooms, Cryptococcus neoformans
basidiomycota (agaricus)
cultivated, edible mushrooms
basidiomycota (amanita)
includes death angel mushrooms
produces amanitin peptide toxin
targets RNA polymerase
basidiomycota (cryptococcus neoformans)
human pathogen, central nervous system
produces capsule
AID and immunocompromised patients