Lecture 14: Hedgehog Signaling in Cancer

Question 1

What are the three types of hedgehog genes in mammals and what are their important functions?

Answer 1

1. Sonic hedgehog - Patterning of early embryo, limb development, facial morphogenesis, neural differentiation.
2. Indian hedgehog- essential for chondrocyte development (bone development)
3. Desert hedgehog- reproductive tissues and in nerve sheath formation