Lecture 13.5 - GPCR Remembering G Protein Second Messengers

Question 1

What is the Pneumonic to remember what GPCRs are associated with what type of G Protein?

Answer 1

QISS QIQ SI QS QS

Question 2

How does the Pneumonic QISS QIQ SI QS QS work?

Kiss Quick Si QS QS

Answer 2

Write out all the letters of the pneumonic and write a1,a2,B1,B2,M1,M2,M3,D1,D2,H1,H2,V1,V2 next to each letter

Q refers to the Gq protein
I refers to the Gi protein
S refers to the Gs protein

Question 3

What is a D1 or D2 receptor?

Si

Answer 3

Dopamine receptor

Question 4

What is a H1 or H2 receptor?

QS

Answer 4

Histamine receptor

Question 5

What is a V1 or V2 receptor?

QS

Answer 5

Vasopressin receptor

Question 6

What type of G protein is associated with a1, a2, B1, B2 adrenergic receptors?

Answer 6

a1 = q
a2 = i
b1 = s
b2 = s

Question 7

What is the agonist that can bind to the a1, a2, B1 and B2 receptors?

QISS

Answer 7

Adrenaline and noradrenaline

Question 8

What is the agonist that can bind to the M1, M2 and M3 muscarinic receptors?

QIQ

Answer 8

ACh (Acetylcholine receptors)

Question 9

What enzyme does a Gs protein stimulate?

Answer 9

Adenylyl cyclase

Question 10

What enzyme does a Gi protein inhibit?

Answer 10

Adenylyl cyclase

Question 11

What enzyme does a Gq protein stimulate?

Answer 11

Phospholipase C

Question 12

What enzyme do Gs and Gi proteins affect?

Answer 12

Adenylyl cyclase