Lecture 13: Personalized Medicine

Question 1

Personalized medicine

Answer 1

Selection of treatment best suited for individual, based on genes and environmental factors

Question 2

Herceptin

Answer 2

aka Trastuzumab
mAb drug targeting breast cancer overexpressing HER2/neu gene

Question 3

Gene factors for warfarin

Answer 3

Oral anticoagulant; pharmokinetic/-kodynamic properties depend on CYP2C9, VKORC1 allele types

Question 4

Gleevec

Answer 4

aka Imatinib
Works in CML/ALL that is Philadelphia chr. positive (Ph+), inhibiting Bcr-Abl tyrosine kinase

Question 5

Kalydeco

Answer 5

aka ivacaftor
Effective in treating CF patients w/ G551D mutation

Question 6

Presymptomatic genes to test for

Answer 6

BRCA1/2: breast/ovarian cancer
MLH1/MSH2: colon cancer

Question 7

Iressa

Answer 7

aka Gefitinib
Lung cancer drug requiring specific genetic companion diagnostic

Question 8

MammaPrint

Answer 8

70-gene signature risk assessment for metastasis in breast cancer patients; gene expression diagnostics

Question 9

Oncotype DX

Answer 9

PCR-based test predicting likelihood of recurrence, chemo effectiveness in breast and colon cancer